Have you heard of nitric oxide supplements? It is touted to be able to help with erectile dysfunction (ED) by improving the blood flow. Nitric oxide works by relaxing the muscles in the blood vessels, allowing for increase blood flow to the penis and helping you achieve and maintain an erection and perform penetrative sex.

Nitric oxide supplements are great for individuals who are considering more natural methods to enhance their body performance, as these compounds are also naturally found in food. While nitric oxide supplements do not cure erectile dysfunction, they are a favourite alternative solution for people with ED to take before having sex as they find it helps them perform during sexual activities.

Another way of achieving an erection if you have erectile dysfunction (ED) is to try a penis pump. There are multiple FDA-approved penis pumps that are medically designed for people with erectile dysfunction (ED) to have an erection and perform penetrative sex.

If you are thinking of improving your diet or using more natural remedies to help you manage your erectile dysfunction (ED) condition, taking supplements could be an alternative method or an added method on top of your existing ways such as using a FDA cock ring during sexual intercourse or using FDA-approved penis pumps.

In this article, you will find the top 5 best Nitric Oxide Supplements that are most suitable to eat for people with erectile dysfunction.

A word of caution, there is little scientific advice or research to support claims that supplements can effectively treat erectile dysfunction (ED). If you are unsure, always seek your doctor’s advice before taking them.

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Top 4 Nitric Oxide Supplement summary

These 4 nitrate oxide supplements are general supplements that are marketed to boost general health. However, they contain ingredients and compounds that are promoted as suitable for people with erectile dysfunction. While they do not cure erectile dysfunction (ED), many users who consume nitric oxide supplements see promising effects on their erections and improvement in their sex life.

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YGP top 4 best Nitric Oxide Supplement for ED in 2025

Best Nitric Oxide Supplement for ED

Features

180 capsules per bottle
60 servings per bottle
Can last for 2 months (if taken per recommended serving)
Non-GMO, soy free, and gluten free
375mg of L-Citrulline, and 375mg of L-Citrulline Malate 2:1 in every serving

Nutricost Nitric Oxide Booster is a very popular nitrate oxide supplement on the market. It contains L-Citrulline and L-Citrulline which is essential for nitric oxide production, and it is recommended that you take 3 capsules daily.

Nutricost Nitric Oxide Booster is formulated to boost blood flow during physical activities, increase energy, and improve endurance. While many users take Nutricost Nitric Oxide Booster as a supplement to improve their performance during exercises and workouts, it is also used by many with erectile dysfunction (ED) to help them perform during sex.

For users with mild to moderate erectile dysfunction (ED), there have been many positive reviews of how nitrate oxide has helped them to stay harder and have a longer erection, allowing them to have a more positive sex life. The effect of nitric oxide is not lasting, as it does not cure ED, rather you can take it an hour before you have sex for the nitrate oxide supplement to take effect.

As an added benefit, nitrate oxide supplement is also a health supplement that helps with muscle recovery and overall boosts heart health, which is why it is a popular supplement amongst fitness fanatics.

Please note that nitrate oxide boosters may interfere with other medications, so it would be best to consult a doctor if you are unsure of the effects.

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Best Supplement with Yohimbine for ED

Features

240 capsules per bottle
5mg of Yohimbine HCl per capsule and 240 servings per bottle
Can last for 8 months (if taken per recommended serving)
Non-GMO, and gluten free

Supplements with yohimbine have been gaining popularity amongst people with erectile dysfunction as more research is supporting yohimbine being a potential cure for erectile dysfunction (ED). While these studies are inconclusive, many users have tried supplements with yohimbine and see that their erections have become harder and they can stay erect longer.

Nutricost Yohimbine HCl is a supplement that contains 5mg of Yohimbine HCl per capsule and 1 capsule per day would improve overall health, such as better focus and improved energy. It is also touted to improve penile health by blocking the receptors responsible for preventing erections. Many users observed that their performance during sex improved if they took Yohimbine an hour before sex.

However, supplements with yohimbine could have very strong side effects, such as sweaty palms and racing hearts. If you are unsure about the effects or are taking other medications, do check with your doctor to understand if it is suitable for you.

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Best Supplement with Pycnogenol for ED

Features

60 capsules per bottle
Comes combined with 240 mg of amla extract
Can last for 2 months (if taken per recommended serving)
Non-GMO, Kosher, Dairy Free, Egg Free, Made without Gluten, Nut Free, Soy Free, Vegan/Vegetarian

Pycnogenol is a type of pine bark extract and works by improving blood flow and antioxidant status. This is beneficial for people with erectile dysfunction (ED) as it helps to improve their blood vessel function and protect the cells from damage. While further studies are still ongoing, many users have tried supplements with pycnogenol and have seen very positive experiences during sexual intercourse.

Many users take NOW Foods Supplements, Pycnogenol 100mg with nitric oxide supplements, and see that their erection can be maintained for longer periods and a boost in the hardness of their erection. While research is still ongoing, it is thought that Pycnogenol also increases testosterone production, which is important for men to have a strong and hard erection.

Ultimately, NOW Foods Supplements, Pycnogenol 100 mg is a health supplement that helps boost energy and improve skin condition. As such, it is priced on the higher side. However, many users have given it a try and have noticed that their erections have been much easier to achieve after taking them for a while.

If you are unsure about the effects or are taking other medications, do check with your doctor to understand if it is suitable for you.

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Best Nitric Oxide Supplement with Extra Strength for ED

Features

180 capsules per bottle
90 servings per bottle
Can last for 3 months (if taken per recommended serving)
Non-GMO
800mg of L-Arginine, and 400mg of L-Citrulline in every serving

Extra Strength Nitric Oxide Supplement is a supplement that provides a higher concentration of L-Arginine and L-Citrulline per serving. Many users who have ED may take nitric oxide supplements before sex to give them the extra boost to perform better.

Depending on your health, the severity of your ED condition, and age, you may need to adjust the dosage of L-Arginine and L-Citrulline for the supplement to take effect. Extra Strength Nitric Oxide Supplement is a stronger supplement with a higher dosage of L-Arginine and L-Citrulline per pill and is great for people who require a higher amount of L-Arginine and L-Citrulline but do not want to consume too many pills.

If you are unsure about the effects or are taking other medications, do check with your doctor to understand if it is suitable for you.

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The Science Behind Nitric Oxide

Our body naturally produces nitric oxide, and it is one of the most important compounds for blood vessel health. This means nitric oxide helps to increase blood flow, which is crucial for men to achieve and maintain their erections.

If you want to increase nitric oxide naturally, you can eat food rich in nitric oxide, such as leafy greens like spinach and kale. Alternatively, you can take supplements with nitric oxide. They don’t contain nitric oxide, rather, they contain compounds like L-citrulline and L-arginine that your body uses to make nitric oxide, and it is very widely used as a health supplement.

How Taking Nitric Oxide Supplements Helps Treat Erectile Dysfunction (ED)

By taking nitric oxide supplements, it helps to improve the blood flow to your penis by relaxing the blood vessels. More blood can flow through and this allows your penis to become and stay erect and enable you to perform penetrative sex.

Suppose you have erectile dysfunction, and are looking for alternative methods to treat erectile dysfunction. In that case, you may have been recommended by your doctor to take nitric oxide supplements that contain both L-arginine and yohimbine. This combination is an approved treatment to help treat mild to moderate erectile dysfunction (ED).

Another combination of compounds that shows promising results for people with ED is L-arginine and Pycnogenol. This is another treatment that helps people with ED achieve normal erections.

Again, note that taking nitric oxide supplements does not restore or cure your Erectile Dysfunction (ED). It is not to be taken as a replacement for ED prescription drugs. Always talk to your doctor if you are unsure, especially so if you are also taking other prescription ED drugs.

You can also read our guide on the 5 Best FDA-Approved Penis Pumps For Those With Erectile Dysfunction (ED).